李熙灿
1970年生，湖南省桂阳县筱塘村人，教授、中药学硕士研究生导师、博士研究生导师、博士后合作导师。“全球2%顶尖科学家”（2020-2025年）。
受教育经历
1987.09 ~ 1991.7, 湖南师范大学, 化学, 学士
1994.09 ~ 1997.07, 华南师范大学, 天然有机化学, 硕士
科研工作经历
1997.08 ~ 至今, 新葡的京集团35222vip, 历任助教、讲师、副教授、教授
研究方向
①中药分析新方法; ②中药质量控制; ③中药《药典》质量标志物与防伪Q-marker; ④中药药效物质; ⑤ 中药抗氧化化学
主要学术成就
① 更新了玉竹、杜仲、杜仲叶、紫花地丁、藏党参等7个单味药的质量标志物，以及金花清感、午时茶、通脉颗粒、脑得生等15个中药复方的质量标志物
② 对中药抗氧化化学进行了比较系统的研究
③ 改进了连苯三酚过氧自由基清除法
④ 发现了脱氧核糖降解法用于测定羟基自由基清除活性中存在的溶剂效应，并予以改进
⑤ 创建了PTIO自由基清除法
科研及教学课题
①主持: 国家自然科学基金面上项目“新型白术内酯促骨髓间充质干细胞向软骨分化的网络共激活机制”（81573558）, 研究周期: 2016-2019. 68.1万元.
②主持: 广东省省级科技计划项目/前沿与关键技术创新/粤港联合创新领域“基于干细胞技术辨析防治骨病的中药有效成分”（2017A050506043）, 研究周期: 2017-2019. 100.0万元(合同金额).
③共同主持团队项目: 广东省科技发展专项资金（基础与应用基础研究）“中药小分子调控iPSCs成软骨分化的网络共激活机制”（2017A030312009）,研究周期: 2017-2021. 总300.0万元.
④共同主持团队项目: 广东省教育厅创新团队项目“补益法调控iPSCs成软骨分化的网络机制” (2017KCXTD007), 研究周期: 2017-2019. 总60.0万元.
⑤ 主持: 国家自然科学基金面上项目“老鹳草桥联鞣质通过WWP2泛素化抗糖尿病软骨细胞铁死亡的相分离机制”（82374485）,研究周期: 2024.01-2027.12. 48.0万元.
⑥ 主持: 全国中医药行业高等教育“十三五”规划教材《有机化学》数字化教学改革, 国家中医药管理局, GJYJS16065,立项日期2016-2019. 1.0万元.
⑦ 主持:中医药数字化教学资源标准化研究/全国中医药行业规划教材《有机化学》标准化数字资源库（题库）建设项目 (省部级, GZY-FJS-2023-005-048),立项日期2023.12. 3.0万元.
承担课程与教材编写
有机化学（含实验）教学工作
《有机化学》副主编, “十二五”至”十五五”行业规划教材, 中国中医药出版社, 2008-2024.
代表性成绩
① 1998年, 新葡的京集团35222vip青年教师讲课比赛第一名
② 2008年, 新葡的京集团35222vip讲课比赛一等奖（最高奖）
③ 2008年, 新葡的京集团35222vip“学生心目中的好老师”
④ 2020-2021年, 入选 “全球2%顶尖科学家”（年度影响力榜第95439位、42545位；爱思唯尔Elsevier）
⑤ 2021-2022年, 入选 “全球顶尖前10万科学家”（第83527位）
⑥ 2022年, 入选 “全球2%顶尖科学家” （终身影响力榜第162553位，年度影响力榜第40642位；爱思唯尔Elsevier）
⑦ 2022年, 入选 “Wiley威立中国开放科学2022年度作者”
⑧ 2023年, 入选 “全球2%顶尖科学家”（终身影响力榜第172386位，年度影响力榜第30631位；爱思唯尔Elsevier）
⑨ 2024年, 入选 “全球2%顶尖科学家”（终身影响力榜第133203位，年度影响力榜第29646位；爱思唯尔Elsevier）
⑩ 2025年, 入选 “全球2%顶尖科学家”（终身影响力榜第123379位，年度影响力榜第34324位；爱思唯尔Elsevier）
⑪ 2009-2025年,共培养硕士研究生31名,博士研究生2名,合作培养博士后1名，其中，国家奖学金17人次、省优秀研究生3人、科技创新奖3人。
代表性论文论著
截至2025年10月，共发表SCI论文114篇, 总影响因子＞400, H=37. 详列如下：
›Hanxiao Chai, Xican Li *, Shaoman Chen, Dan Lin, Rongxin Cai, Anyuang Yang, Cuiling Pan, Jianwu Li, Difang Deng. Comparative Study Between Orah Mandarin Peel and TraditionalMandarin Peels (Chenpi) Based on Data-Repository-Enabled Ultra-High-Performance Liquid Chromatography-Quadrupole-Orbitrap-Mass Spectrometry Analysis, Chemistry and Biodiversity, 2025, DOI 10.1002/cbdv.202501661. 陈皮
›Yongbai Liang#,Xican Li *,#, Xi Zhao, Rongxin Cai, Shaoman Chen, Rongrong Lin, Hanxiao Chai, Chunhou Li. Simultaneous Semi-quantification and Docking Simulation of 43 Compounds Reveal Bioactive Difference between Phenolics and Alkaloids in Fresh Edible Areca Nut. Natural Product Research, 2025, DOI 10.1080/14786419.2025.2571852 槟榔
›Xi Zhao, Xican Li *, Yongbai Liang, Rongxin Cai, Hanxiao Chai, Yue Sun, Lijia Yuan, Caixia Li. Mining 26 “Unexcavated” Compounds in Polygonati odorati and Proposing 1-Kestose as Yuzhu′s new Pharmacopoeia Quality-marker Using Authentic Standards-aided UHPLC-Q-Orbitrap-MS/MS. Microchemical Journal. 2025, 218, 115504. 玉竹
›Xican Li*, Jingyuan Zeng, Chunhou Li, Hanxiao Chai, Shaoman Chen, Nana Jin, Tingshan Chen, Xiaohua, Sunbal Khan, Rongxin Cai. Simultaneous Qualitative and Quantitative Determination of 33 Compounds from Rubus Alceifolius Poir Leaves Using UHPLC-Q-Orbitrap-MS Analysis. Current Analytical Chemistry. 2025, 21(5), 535-546. 粗叶悬钩子
›Rongxin Cai, Xican Li*, Honghong Liang, Shaoman Chen, Yuting Huang, Hanxiao Chai, Rongrong Lin, Guihua Jiang*. High-Resolution LC-MS Simultaneous Quantification of Forty-Six Compounds from Jatropha podagrica Fruit Recommends Four Top Antioxidant Contributors as Q-Markers. Molecules. 2025, 30(3), 722. 佛肚树果
›Rongxin Cai, Honghong Liang, Xican Li*, Hanxiao Chai, Yongbai Liang, Yuhan Huang, Meilin He, Guihua Jiang*. Multiple ionization patterns enable UHPLC-Q-Orbitrap MS/MS to quantify 80 compounds in Tongmai Granule and recommend new anti-counterfeiting Q-markers for Pharmacopoeia. Journal of Saudi Chemical Society. 2025, 29, 9. 通脉颗粒
›Ban Chen, Shuangshuang Liu, Huiyin Xia, Xican Li*, Rongxin Cai, Yingqing Zhang, Yuchen Hu, Jiangtao Su. Integrated strategy for screening direct Keap1-Nrf2 PPI inhibitors from traditional Chinese medicine: a case study of Achyranthis bidentatae Radix. Journal of Computer-Aided Molecular Design. 2025, 39, 83. 牛膝
›Ban Chen, Shuangshuang Liu, Huiyin Xia, Xican Li, Yingqing Zhang*. Computer-Aided Drug Design in Research on Chinese Materia Medica: Methods, Applications, Advantages, and Challenges. Pharmaceutics. 2025, 17(3), 315.
›Minhui Zhang, Shuyu Bao, Zheng Ke, Haili Sun, Yejia Li, Xican Li, Quanzhou Wu*, Jianfeng He*. Highly specific molecularly imprinted microspheres prepared based on dopamine/polyethyleneimine coating and carboxyl-functionalized POSS supports for selective separation of cepharanthine. Separation and Purification Technology. 2025, 36,1.
›Shanyu Ye, Yanqing Wang, Ziwei Luo, Aijun Liu, Xican Li, Jiasong Guo, Wei Zhao, Dongfeng Chen*, Lin Yang*, Helu Liu*. E3 ligase Trim63 promotes the chondrogenic differentiation of mesenchymal stem cells by catalyzing K27-linked cysteine ubiquitination of Myh11. Stem Cells. 2025, 43(7), sxaf017.
›Jianwu Li, Hanxiao Chai, Xican Li*, Shaoman Chen, Rongxin Cai, Lanying Wang, Xiaoqiong Xu, Zhenhui Chen. Simultaneous Quantification of 22 Compounds in Talinum paniculatum Root and Proposal Three anti-counterfeiting Quality-markers Using Library-aided UHPLC-Q-Orbitrap-MS/MS Method Phytochemical analysis. 2025, 36(6), 1778-1789. 土人参
›Chunhou Li, Xican Li*, Jingyuan Zeng, Rongxin Cai, Shaoman Chen, Ban Chen, Xiaojun Zhao. Detection of Adulterated Naodesheng Tablet (Naodesheng Pian) via In‑Depth Chemical Analysis and Subsequent Reconstruction of Its Pharmacopoeia Q‑Markers. Molecules. 2024, 29(6), 1392. 脑得生片
›Ban Chen, Shuangshuang Liu, Xican Li*, Rongxin Cai, Chunhou Li, Yuchen Hu, Jiangtao Su, Tongxun Lei. Database-aided ultrahigh-performance liquid chromatography Q-Exactive-Orbitrap tandem mass spectrometry putatively identifies 16 unexpected compounds and three anticounterfeiting pharmacopoeia quality markers for Perillae Fructus. Rapid Communications in Mass Spectrometry. 2024, 38(13), e9762. 紫苏籽
›Ban Chen, Shuangshuang Liu, Xican Li*, Chunhou Li, Rongxin Cai, Jingyuan Zeng, Yuchen Hu, Jiangtao Su, Shaoman Chen. Re-construction of quality marker system for Ginkgo Folium tablet using UHPLC-Q-Orbitrap MS, quantum chemical calculation, network pharmacology, and molecular simulation. Phytochemical analysis. 2024, 35(7), 1659-1673. 银杏叶片
›Shaoman Chen, Xican Li*, Chunhou Li, Rongxin Cai, Jingyuan Zeng, Ban Chen, Guihua Jiang, Yongbai Liang, Xu Chen. Putative identification and Semi-quantification of 37 Compounds from Violae Herba (Zihuadiding) to Propose its Anti-counterfeiting Pharmacopoeia Quality-marker via UHPLC-Q-Orbitrap-MS/MS Tool. Chromatographia. 2024, DOI: 10.1007/s10337-024-04348-6. 紫花地丁
›Rongrong Lin, Xican Li*, Shuqin Liu, Rongxin Cai, Jingyuan Zeng, Ziwei Luo, Jianfeng He. Integrated UHPLC-Q-Exactive-Orbitrap MS/MS and ABTS analyses screen antioxidant and anti-counterfeiting marker of Eucommiae Cortex (Duzhong) for Pharmacopoeias. Microchemical Journal. 2024, 204, 111124. 杜仲
›Xican Li*, Jingyuan Zeng, Rongxin Cai, Chunhou Li, Xiaoshan Chen, Ban Chen, Xiaojun Zhao, Sunbal Khan. Putative Identification of 47 Compounds from Jieyu Anshen Granule and Proposal of Pharmacopeia Quality-Assessment Strategy Using TCM-Specific Library with UHPLC-Q-Exactive-Orbitrap-MS. Chemistry Open. 2024, 14(1), e202400046. 解郁安神颗粒
›Xiaoqiong Xu*, Xican Li*, Shaoman Chen, Yongbai Liang, Chuanyang Zhang, Yuhan Huang*. Simultaneous Qualitative and Quantitative Analyses of 41 Constituents in Uvaria macrophylla Leaves Screen Antioxidant Quality-Markers Using Database-Affinity Ultra-High-Performance Liquid Chromatography with Quadrupole Orbitrap Tandem Mass Spectrometry. Molecules. 2024, 29(20), 4886. 紫玉盘
›Zhouli Xu, Rongxin Cai, Hanxiao Chai, Shaoman Chen, Yongbai Liang, Xican Li*, Guihua Jiang *. Simultaneous Quantification of 66 Compounds in Two Tibetan Codonopsis Species Reveals Four Chemical Features by Database-Enabled UHPLC-Q-Orbitrap-MS/MS Analysis. Molecules. 2024, 29(21), 5203. 藏党参
›Yanqing Wang#, Xi Zhao#, Ban Chen, Shaoman Chen, Yongbai Liang, Dongfeng Chen*, Xican Li*. Methylophiopogonanone A Inhibits Ferroptosis in H9c2 Cells: An Experimental and Molecular Simulation Study. Molecules. 2024, 29(23), 5764.
›Jingyuan Zeng, Xican Li*, Rongxin Cai, Ban Chen, Chunhou Li, Qingzhong Hu, Yue Sun. Proposing Anti-counterfeiting Pharmacopoeia Quality-markers for Shenlingbaizhu Granule Based on UHPLC-Q-Orbitrap-MS Identification. Phytochemical analysis. 2024, 35(2), 220-238. 参苓白术颗粒
›Fangping Liang, Wurong Li, Mingao Li, Xican Li, Jianfeng He*, Quanzhou Wu*. Kaempferol molecularly imprinted polymers: Preparation, characterization and application to the direct extraction of kaempferol from Ginkgo leaves. Polymer International. 2023, 72, 586-596. 银杏叶
›Xican Li*, Xiaojian Ouyang, Ban Chen, Shuqin Liu, Jingyuan Zeng. Linkage and Stereochemistry Characters of Phenolic Antioxidant Product Formation. Journal of Agricultural & Food Chemistry. 2023, 71(13), 5382-5390.
›Jiapei Huang, Lan Yi, Xiaoxiao Yang, Qi Zheng, Jun Zhong, Sen Ye, Xican Li, Hui Li*, Dongfeng Chen*, Caixia Li*. Neural Stem Cells Transplantation Combined with Ethyl Stearate Improve PD rats Motor Behavior by Promoting NSCs Migration and Differentiation. CNS Neuroscience & Therapeutics. 2023, 29(6), 1571-1584.
›Jiangtao Su, Dan Li, Yuchen Hu, Xiangyu You, Xiaoxia Guo, Xican Li, Ban Chen*. A novel C6-sulfonated celastrol analog as a tyrosinase and melanin inhibitor: Design, synthesis, biological evaluation and molecular simulation. Journal of Molecular Structure. 2023, 1283, 135288.
›Shuqin Liu, Xican Li*, Rongxin Cai, Ban Chen, Jingyuan Zeng, Chunhou Li, Xianxi Zhou, Yueying Li. Ultra-high-performance liquid chromatography-Quadrupole-Exactive-Orbitrap-tandem mass spectrometry-based putative identification for Eucommiae Folium (Duzhongye) and its quality-marker candidate for pharmacopeia. Journal of Separation Science. 2023, 46, 13. 杜仲叶
›Yizhou X, Yizhou Xu, Xiaofang Hu, Jiale Cai, Yunlun Li, Ying Zou, Yihan Wang, Changnan Xie, Shuyi Xu, Yanqing Wang, Yuli Zheng, Djibril Adam Mahamat, Yuantao Xu, Xianghai Wang, Xican Li, Aijun Liu, Dongfeng Chen, Lixin Zhu, Jiasong Guo*. Atractylenolide-III alleviates osteoarthritis and chondrocyte senescence by targeting NF-κB signaling. Phytotherapy Research. 2023, 37(10), 4607-4620.
›Jingyuan Zeng, Xican Li*, Rongxin Cai, Chunhou Li, Shaoman Chen, Jinhua Qing, gan Granule. UHPLC-Q-Extractive-Orbitrap-MS Assay: Putative Identification of 45 Potential Anti-Covid-19 Constituents, Confidential Addition, and Pharmacopoeia Quality-markers Recommendation. Journal of Food and Drug Analysis. 2023, 31, 534-551. 金花清感颗粒
›Xican Li*#, Jingyuan Zeng#, Rongxin Cai, Chunhou Li. New UHPLC-Q-Orbitrap MS/MS-based Library-comparison Method Simultaneously Distinguishes 22 Phytophenol Isomers from Desmodium styracifolium. Microchemical Journal. 2023, 191, 108938. 广金钱草
›Ban Chen, Xiaojian Ouyang*, Chunfeng Cheng, Dongfeng Chen, Jiangtao Su, Yuchen Hua, Xican Li*. Bioactive peptides derived from Radix Angelicae sinensis inhibit ferroptosis in HT22 cells through direct Keap1-Nrf2 PPI inhibition. RSC Advances. 2023, 13, 22148-22157.
›Xican Li*, Shaoman Chen, Jingyuan Zeng, Rongxin Cai, Yilan Liang, Chuanbin Chen, Ban Chen, Chunhou Li. Database-aided UHPLC-Q-orbitrap MS/MS Strategy Putatively Identifies 52 Compounds from Wushicha Granule to Propose Anti-counterfeiting Quality-markers for Pharmacopoeia. Chinese Medicine. 2023, 18(1), 116. 午时茶
›Shaoman Chen, Xican Li*, Jingyuan Zeng, Rongxin Cai, Chunhou Li, Chuanbing Chen. Library-based UHPLC-Q-Exactive-Orbitrap-MS Putative Identification of Isomeric and Non-isomeric Bioactives from Zibushengfa Tablet and Pharmacopoeia Quality-marker Chemistry. Journal of Liquid Chromatography & Related Technologies. 2023, 46, 153-167. 滋补生发片
›Ban Chen, Jiangtao Su, Yuchen Hu, Shuqin Liu, Xiaojian Ouyang, Rongxin Cai, Xiangyu You, Xican Li*. Antioxidant mechanisms and products of four 4, 5, 7-trihydroxyflavonoids with different structural types. RSC Medicinal Chemistry. 2023, 14, 173-182.
›Lan Yi, Haisheng Ma, Xiaoxiao Yang, Qi Zheng, Jun Zhong, Sen Ye, Xican Li, Dongfeng Chen, Hui Li*, Caixia Li*. Cotransplantation of NSCs and ethyl stearate promotes synaptic plasticity in PD rats by Drd1/ERK/AP-1 signaling pathway. Journal of Ethnopharmacology. 2023, 18, 116.
›Yamei Liu, Binlan Fu, Xiaoman Li, Chen Chen, Xican Li, Liangliang Xu*, Bin Wang*. Bushen huoxue decoction inhibits RANKL-stimulated osteoclastogenesis and glucocorticoid-induced bone loss by modulating the NF-κB, ERK, and JNK signaling pathways. Frontiers in Pharmacology. 2022, 3,1007839. 补肾活血汤
›Lin Yang , Zhenxing Ren, Shenyu Yan, Ling Zhao, Jie Liu, Lijun Zhao, Zhen Li, Shanyu Ye, Aijun Liu, Xichan Li, Jiasong Guo, Wei Zhao, Weihong Kuang, Helu Liu, Dongfeng Chen. Nsun4 and Mettl3 mediated translational reprogramming of Sox9 promotes BMSC chondrogenic differentiation. Communications Biology. 2022, 5, 495.
›Shuqin Liu, Xican Li*, Ban Chen, Xiaojian Ouyang, Yulu Xie, Dongfeng Chen*. Phytophenol Dimerization Reaction: From Basic Rules to Diastereoselectivity and Beyond. Molecules. 2022, 27(15), 4842.
›Xican Li*, Shuqin Liu, Jingyuan Zeng, Rongxing Cai, Chunhou Li, Ban Chen, Dongfeng Chen*. Laccase Catalyses Phytophenol Furanocyclic Dimerization: Substrate Specificity and Diastereoselective Process. Journal of Molecular Structure. 2022, 1274, 134425.
›Rongxin Cai, Xican Li *, Chunhou Li, Jiayi Zhu, Jingyuan Zeng, Jianwu Li, Boxu Tang, Zheng Li, Shuqin Liu, Yan Yan. Standards-Based UPLC-Q-Exactive Orbitrap MS Systematically Identifies 36 Bioactive Compounds in Ampelopsis grossedentata (Vine Tea). Separations. 2022, 9, 329. 藤茶
›Ban Chen, Xican Li *, Jie Liu, Yuling Li, Wanjian Dai, Yingci Chen, Dongfeng Chen* . Ferroptosis-Inhibitory Effect and Possible Mechanisms of Ellagitannin Geraniin. Chemistry Open. 2021, 10, 737-739.
›Ban Chen, Xican Li*, Xiaojian Ouyang, Jie Liu, Yangping Liu, Dongfeng Chen* .Comparison of Ferroptosis-inhibitory Mechanisms between Ferrostatin-1 and Dietary Stilbenes (Piceatannol and Astringin). Molecules. 2021, 26, 1092.
›Yangping Liu, Xican Li*, Yujie Hua, Wenhui Zhang, Xianxi Zhou, Jianfeng He, Dongfeng Chen*. Tannic Acid as a Natural Ferroptosis Inhibitor: Mechanisms and Beneficial Role of 3-O-Galloylation. ChemistrySelect. 2021, 6(7), 1562-1569.
›Yujie Hua, Xican Li*, Wenhui Zhang, Ban Chen, Yamei Liu, Xiaojun Zhao, Hong Xie, Dongfeng Chen. Antioxidant product analysis of Folium Hibisci Mutabilis. Journal of Saudi Chemical Society. 2021, 25, 101272. 木芙蓉叶
›Sen Ye, Jun Zhong, Jiapei Huang, Lichun Chen, Lan Yi, Xican Li, Jianping Lv, Jifei Miao, Hui Li*, Dongfeng Chen*, Caixia Li*. Protective effect of plastrum testudinis extract on dopaminergic neurons in a Parkinson's disease model through DNMT1 nuclear translocation and SNCA's methylation. Biomedicine & Pharmacotherapy. 2021, 141, 111832.
›Lin Yang, Yangping Liu, Wenhui Zhang, Yujie Hua, Ban Chen, Quanzhou Wu, Dongfeng Chen, Shuqin Liu, Xican Li*. Ferroptosis-Inhibitory Difference between Chebulagic Acid and Chebulinic Acid Indicates Beneficial Role of HHDP. Molecules. 2021, 26(14), 4300.
›Wenhui Zhang, Xican Li*, Yujie Hua, Zhen Li, Ban Chen, Aijun Liu, Wenbiao Lu, Xiaojun Zhao, Yuanming Diao, Dongfeng Chen*. Antioxidant Product Analysis of Hulu Tea (Tadehagi triquetrum). New Journal of Chemistry. 2021, 45, 20257. 葫芦茶
›Xican Li*, Tingting Wang, Jingjing Liu, Yulong Liu, Jun Zhang, Jian Lin, Zhongxiang Zhao, Dongfeng Chen*. Effect and mechanism of wedelolactone as antioxidant-coumestan on •OH-treated mesenchymal stem cells. Arabian Journal of Chemistry, 2020, 13(1), 184-192.
›Jie Liu, Xican Li*, Rongxin Cai, Ziwei Ren, Aizhen Zhang, Fangdan Deng, Dongfeng Chen*. Simultaneous Study of Anti-Ferroptosis and Antioxidant Mechanisms of Butein and (S)-Butin. Molecules. 2020, 25, 674.
›Xican Li*, Jingyuan Zeng, Yangping Liu, Minshi Liang, Qianru Liu, Zhen Li, Xiaojun Zhao, Dongfeng Chen*. Inhibitory Effect and Mechanism of Action of Quercetin and Quercetin Diels-Alder anti-Dimer on Erastin-Induced Ferroptosis in Bone Marrow-Derived Mesenchymal Stem Cells. Antioxidants. 2020, 9, 205.
›Jun Zhong, Sen Ye, Xiaoli Zhou, Jiapei Huang, Xican Li, Saixia Zhang, Jianhong Zhou, Dongfeng Chen, Caixia Li*. Plastrum Testudinis Extracts Promote NSC Differentiation into Dopaminergic Neuron by Regulating the Interaction of TET1 and FoxA2. Evidence-Based Complementary and Alternative Medicine. 2020, 1, 9104135. 龟板
›Yamei Liu, Liangliang Xu, Liuchao Hu, Dongfeng Chen, Lijuan Yu, Xican Li , Hongtai Chen, Junlang Zhu, Chen Chen, Yiwen Luo*, Bin Wang*, Gang Li*. Stearic acid methyl ester promotes migration of mesenchymal stem cells and accelerates cartilage defect repair. Journal of Orthopaedic Translation. 2020, 22, 81-91.
›Xiaojian Ouyang, Xican Li*, Jie Liu, Yangping Liu, Yulu Xie, Zhongcun Du, Hong Xie, Ban Chen, Wenbiao Lu, Dongfeng Chen*. Structure-activity Relationship and Mechanism of Four Monostilbenes with Respect to Ferroptosis Inhibition. RSC Advances. 2020, 10, 31171-31179.
›Hao Pan*, Yuqing Lin, Jianping Dou, Zhen Fu, Yanqing Yao, Shanyu Ye, Saixia Zhang, Neng Wang, Aijun Liu, Xican Li, Fengxue Zhang, Dongfeng Chen*. Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis. Cell Proliferation. 2020, 53(9), e12868.
›Xican Li*, Jie Liu, Ban Chen, Yingci Chen, Wanjian Dai, Yuling Li, Meiling Zhu*. Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1, 3, 6-Tri- O-galloyl-β-D-glucopyranose. ACS Med. Chemical Letter. 2020, 11, 11.
›Yuqing Lin, Tianyu Luo, Anli Weng, Xiaodi Huang, Yanqing Ya, Zhen Fu, Yingwei Li, Aijun Liu, Xican Li , Dongfeng Chen*, Hao Pan*. Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling. Frontiers in immunology. 2020, 11, 580593.
›Minshi Liang#, Xican Li #, * , Xiaojian Ouyang , Hong Xie, Dongfeng Chen*. Antioxidant Mechanisms of Echinatin and Licochalcone A. Molecules. 2019, 23, 3.
›Rongxin Cai, * Xican Li, * Ban Chen, Yulu Xie, Hong Xie, Dongfeng Chen. Antioxidant Change in Biosynthesis from Naringenin Chalcone to Flavonoid Apingenin. ChemistrySelect. 2019, 4, 5155-5159.
›Xican Li*, Xiaojian Ouyang, Rongxin Cai, Dongfeng Chen*. 3, 8-Dimerization Enhances the Antioxidant Capacity of Flavonoids: Evidence from Acacetin and Isoginkgetin. Molecules 2019, 24(11), 2039.
›Yamei Liu, Wangyang Li, Liangliang Xu, Lijuan Yu, Yiwen Luo, Xican Li, Xunchao Zhang, Yunpu Xiong, Hongtai Chen, Junlang Zhu, Chen Chen, Yulu Xie, Dongfeng Chen*, Bin Wang*. Catharmus tinctorius volatile oil promote the migration of mesenchymal stem cells via ROCK2/Myosin light chain signaling. Chinese Journal of Natural Medicines. 2019, 17(7), 0506-0516. 红花
›Xican Li *#, Xiaojian Ouyang#, Minshi Liang, Dongfeng Chen*. Comparative Analysis of Radical Adduct Formation(RAF)Products and Antioxidant Pathways between Myricetin-3-O-Galactoside and Myricetin Aglycone. Molecules. 2019, 24(15), 2769.
›Ban Chen, Xican Li*, Jie Liu, Wei Qin, Minshi Liang, Qianru Liu, Dongfeng Chen*. Antioxidant and Cytoprotective Effects of Pyrola decorata H. Andres and Its Five Phenolic Components. BMC Complementary and Alternative Medicine. 2019, 19, 275. 鹿衔草
›Biao Huang, Bin Wang, Wayne Yuk-Wai Lee, Kin Pong U, Kam Tong Leung, Xican Li, Zhenqing Liu, Rui Chen, Jiacheng Lin, Lai Ling Tsang, Baohua Liu, Yechun Ruan, Hsiao Chang Chan, Gang Li, Xiaohua Jiang*. KDM3A and KDM4C regulate mesenchymal stromal cell senescence and bone aging via condensin-mediated heterochromatin reorganization. iScience. 2019.21,375-390.
›Xican Li*, Ke Li, Hong Xie, Yulu Xie, Yueying Li, Xiaojun Zhao, Xiaohua Jiang, Dongfeng Chen*. Antioxidant and Cytoprotective Effects of the Di-O-Caffeoylquinic Acid Family: The Mechanism, StructureActivity Relationship, and Conformational Effect Conformational Effect. Molecules. 2018, 23(1), 222.
›Yage Tian#, Xican Li*#, Hong Xie, XiaozhenWang, Yulu Xie, Chuanbing Chen, Dongfeng Chen*. Protective Mechanism of the Antioxidant Baicalein toward Hydroxyl Radical-Treated Bone Marrow-Derived Mesenchymal Stem Cells. Molecules. 2018, 23(1), 223.
›Hong Xie#, Xican Li*#, Zhenxing Ren, Weimin Qiu, Jianlan Chen, Qian Jiang, Ban Chen, Dongfeng Chen*. Antioxidant and Cytoprotective Effects of Tibetan Tea and its Phenolic Components. Molecules. 2018, 23(2), 179. 藏茶
›Xican Li*, #, Yulu Xie#, Ke Li, Aizhi Wu*, Hong Xie, Qian Guo, Penghui Xue, Yerkingul Maleshibek, Wei Zhao, Jiasong Guo, Dongfeng Chen. Antioxidation and Cytoprotection of Acteoside and Its Derivatives: Comparison and Mechanistic Chemistry. Molecules. 2018, 23(2), 498.
›Xican Li*,#, Yulu Xie#, Hong Xie, Jian Yang, Dongfeng Chen*. π -π Conjugation Enhances Oligostilbene′s Antioxidant Capacity: Evidence from α-Viniferin and Caraphenol A. Molecules. 2018, 23(3), 694.
›Xican Li*#, Hong Xie#, Ruicai Zhan, Dongfeng Chen*. Effect of Double Bond Position on 2-Phenyl-benzofuran Antioxidants: A Comparative Study of Moracin C and Iso-Moracin C. Molecules. 2018, 23(4), 754.
›Xican Li*#, Jian Lin#, Ban Chen, Hong Xie, Dongfeng Chen*. Antioxidant and Cytoprotective Effects of Kukoamines A and B: Comparison and Positional Isomeric Effect. Molecules. 2018, 23(4), 973.
›Xican Li*, Ban Chen, Hong Xie, Yuhua He, Dewei Zhong , Dongfeng Chen*. Antioxidant Structure-Activity Relationship Analysis of Five Dihydrochalcones. Molecules. 2018, 23(5), 1162.
›Jian Lin, Xican Li*, Ban Chen , Gang Wei , Dongfeng Chen*. E-Configuration Improves Antioxidant and Cytoprotective Capacities of Resveratrols. Molecules. 2018, 23(7), 1790.
›Xican Li*, Ban Chen, Xiaojun Zhao, Dongfeng Chen*. 2-Phenyl-4, 4, 5, 5-tetramethylimidazoline-1-oxyl 3-oxide Radical (PTIO•) trapping Activity, Mechanisms, and Structure-activity of 16 phenolic Xanthones. Molecules. 2018, 23(7), 1692.
›Fu Yuan Yang, Rui Chen, Xiaohu Zhang, Biao Huang, Lai Ling Tsang, Xican Li, Xiaohua Jiang*. Preconditioning Enhances the Therapeutic Effects of Mesenchymal Stem Cells on Colitis Through PGE2-Mediated T-Cell Modulation. Cell Transplant. 2018, 27(9), 1352-1367.
›Yulu Xie#, Xican Li, *, #, Jingyu Chen, Yuman Deng , Wenbiao Lu, Dongfeng Chen*. pH Effect and Chemical Mechanisms of Antioxidant Higenamine. Molecules. 2018, 23, 2176.
›Xican Li*, Qian Jiang, Ban Chen, Xiaoling Luo, Dongfeng Chen*. Structure-activity Relationship and Prediction of Electron-transfer Potential of Xanthones Series. Chemistry Open. 2018, 7, 730-736.
›Xican Li *#, Zhenxing Ren #, Zimei Wu , Zhen Fu, Hong Xie, Langyu Deng, Xiaohua Jiang, Dongfeng Chen*. Steric Effect of Antioxidant Diels-Alder-Type Adducts: A Comparison of Sanggenon C with Sanggenon D. Molecules. 2018, 23(10), 2610.
›Qianru Liu #, Xican Li#*, Xiaojian Ouyang, Dongfeng Chen*. Dual Effect of Glucuronidation of a Pyrogallol-type Phytophenol Antioxidant: A Comparison between Scutellarein and Scutellarin. Molecules. 2018, 23(12), 3225.
›Xican Li *. Comparative Study of 1, 1-Diphenyl-2-picryl-hydrazyl Radical (DPPH•) Scavenging Capacity of the Antioxidant Xanthones Family. ChemistrySelect. 2018, 3(46), 13081-13086.
›Xiaojian Ouyang #, Xican Li#, *, Wenbiao Lu, Xiaojun Zhao, Dongfeng Chen*. A Null B-Ring Improves the Antioxidant Levels of Flavonol: A Comparative Study between Galangin and 3, 5, 7-Trihydroxychromone. Molecules. 2018, 23(12), 3083.
›Qian Jiang, Xican Li*, Yage Tian, Qiaoqi Lin, Hong Xie, Wenbiao Lu, Yuguang Chi, Dongfeng Chen*. Lyophilized aqueous extracts of Mori Fructus and Mori Ramulus protect Mesenchymal stem cells from •OH-treated damage: bioassay and antioxidant mechanism. BMC Complementary and Alternative Medicine. 2017, 17(1), 242.
›Xican Li*. 2-Phenyl-4, 4, 5, 5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO•) Radical-scavenging: A New and Simple Antioxidant Assay In Vitro. Journal of Agricultural & Food Chemistry. 2017, 65(30), 6288-6297.
›Xican Li* , Yage Tian, Tingting Wang, Qiaoqi Lin, Xiaoyi Feng, Qian Jiang, Yamei Liu, Dongfeng Chen*. Role of the p-Coumaroyl Moiety in the Antioxidant and Cytoprotective Effects of Flavonoid Glycosides: Comparison of Astragalin and Tiliroside. Molecules. 2017, 22(7), 1165.
›Yulu Xie, Xican Li*, Jieying Xu, Qian Jiang, Hong Xie, Jianfeng He, Dongfeng Chen*. Two phenolic antioxidants in Suoyang enhance viability of •OH-damaged mesenchymal stem cells: comparison and mechanistic chemistry. Chemistry Central Journal. 2017, 11(1), 84. 锁阳
›Xican Li*# , Hong Xi#, Qian Jiang, Gang Wei, Lishan Lin, Changying Li, Xingmei Ou, Lichan Yang, Yulu Xie, Zhen Fu, Yamei Liu, Dongfeng Chen*. The mechanism of (+)-taxifolin′s protective antioxidant effect for •OH-treated bone marrow-derived mesenchymal stem cells. Cellular & Molecular Biology Letters, 2017, 22(1), 31.
›Qian Jiang, Xican Li*, Yage Tian, Qiaoqi Lin, Hong Xie, Wenbiao Lu, Yuguang Chi, Dongfeng Chen*. Lyophilized aqueous extracts of Mori Fructus and Mori Ramulus protect Mesenchymal stem cells from •OH-treated damage: bioassay and antioxidant mechanism. BMC Complementary and Alternative Medicine, 2017, 17(1), 242 2017. 桑葚、桑枝
›Xican Li*, Jing Lin, Yaoxiang Gao, Ruimin Tian, Dongfeng Chen*. Nitric Oxide (NO) as Antioxidant Protects HT22 Cells and Biomolecules against Fenton’s Reagent-Induced Damages via Multiple Pathways. Chemistry Select. 2016, 3, 585-589.
›Xican Li*, Lu Han, Yunrong Li, Jing Zhang, Jiemin Chen, Wenbiao Lu, Xiaojun Zhao, Yingtao Lai, Dongfeng Chen, Gang Wei*. Protective Effect of Sinapine against Hydroxyl Radical-Induced Damage to Mesenchymal Stem Cells and Possible Mechanisms. Chem. Pharm. Bull. 2016, 64, 319-325.
›Xican Li*, Jingjing Liu, Jian Lin, Tingting Wang, Jieyuan Huang, Yongqiang Lin, Dongfeng Chen*. Protective Effects of Dihydromyricetin against •OH-Induced Mesenchymal Stem Cells Damage and Mechanistic Chemistry. Molecules. 2016, 21(5), 604.
›Xican Li, Jingjing Liu, Zhong-xiang Zhao*, Tingting Wang, Jian Lin, Dongfeng Chen*Effects of Natural Chalcone-Tannin Hybrids Protecting Mesenchymal Stem Cells against ROS-mediated Oxidative Damage and Indexes for Antioxidant Mechanisms. Chemistry Letters. 2016, 45(7), 743-745.
›Xican Li*, Qian Jiang , Tingting Wang, Jingjing Liu, Dongfeng Chen*. Comparison of the Antioxidant Effects of Quercitrin and Isoquercitrin: Understanding the Role of the 6″-OH Group. Molecules. 2016, 21(9), 1246.
›Jingjing Liu, Xican Li*, Jian Lin, Yunrong Li , Tingting Wang, Qian Jiang, Dongfeng Chen*. Sarcandra glabra (Caoshanhu) Protects Mesenchymal Stem Cells from Oxidative Stress: A Bioevaluation and Mechanistic Chemistry. BMC Complementary and Alternative Medicine. 2016, 16, 423. 草珊瑚
›Tingting Wang, Xican Li*, Yunrong Li , Jianrun Wu, Yuyin Huang, , Gang Wei, Dongfeng Chen. Mechanistic Chemistry of Extraordinary Capacity of Salvianolic Acid B on Oxidatively-Damaged Mesenchymal Stem Cells. Journal of the Chinese Chemical Society, 2016, 63( 11), 924-929.
›Xican Li*, Qian Fang, Jing Lin, Zhengpeng Yuan, Lu Han, Yaoxiang Gao. Chemistry Study on Protective Effect against •OH-induced DNA Damage and Antioxidant Mechanism of Cortex Magnoliae Officinalis. Bulletin of the Korean Chemical Society, 2014, 35, 117-122. 厚朴
›Jian Lin, Xican Li*, Lu Han, Fei Li, Wenbiao Lu, Ye Bai, Dongfeng Chen*. Folium Sennae Protects against Hydroxyl Radical-induced DNA Damage via Antioxidant Mechanism: An in vitro Study. Botanical studies. 2014, 55, 16. 番泻叶
›Xican Li*, Li Wang, Weijuan Han, Wenqiong Mai, Lu Han, Dongfeng Chen. Amentoflavone Protects against Hydroxyl Radical-induced DNA Damage via Antioxidant MechanismTurkish. Journal of Biochemistry, 2014, 39, 30-36.
›Xican Li*, Wenqiong Mai, Dongfeng Chen*. Chemical study on protective effect against hydroxyl-induced DNA damage and antioxidant mechanism of myricitrin. Journal of the Chinese Chemical Society, 2014, 61, 383-391.
›Jing Lin, Xican Li*, Li Chen, Weizhao Lu, Xianwen Chen, Lu Han, Dongfeng Chen*. Protective effect against hydroxyl radical-induced DNA damage and antioxidant mechanism of [6]-gingerol: A Chemical Study. Bulletin of the Korean Chemical Society, 2014, 35(6), 1633-1638.
›Xican Li*, Qiuping Hu, Shuxia Jiang, Fei Li, Jian Lin, Lu Han, Yuling Hong, Wenbiao Lu, Yaoxiang Gao, Dongfeng Chen. Flos Chrysanthemi Indici Protects against Hydroxyl-induced Damages to DNA and MSCs via Antioxidant Mechanism: A Chemistry Study. Journal of Saudi Chemical Society, 2015, 19, 454-460. 野菊花
›Xican Li*, Yaoxiang Gao, Fei Li, Aifeng Liang, Zhiming Xu, Ye Bai, Wenqiong Mai, Lu Han, Dongfeng Chen*. Maclurin Protects against Hydroxyl Radical-induced Damages to Mesenchymal Stem Cells: Antioxidant Evaluation and Mechanistic Insight. Chemico-Biological Interactions, 2014, 219, 221-228.
›Lu Han, Chengjie Sun, Jian Lin, Zisheng Wu, Ye Bai, Fei Li, Xican Li*, Wenqiong Mai. Dongfeng Chen. Herba Ecliptae Protects against Hydroxyl Radical-induced Damages to DNA and Mesenchymal Stem Cells via Antioxidant MechanismJournal of the Chinese. Chemical Society. 2014, 61,1161-1167. 墨旱莲
›Xican Li*, Yaoxiang Gao, Weijuan Han, Jing Lin, Qiuping Hu, Dongfeng Chen*. Antioxidant activity and its mechanism for flower of Hylocereus Undatus(Haw.)Britt. et Rose. Acta Biologica Cracoviens: Series Botanica. 2013, 55, 80-85. 霸王花
›Xican Li*, Weijuan Han, Wengqiong Mai, Li Wang. Antioxidant Activity and Mechanism of Tetrahydroamentoflavone in vitro. Natural Product Communications. 2013, 8, 787-789.
›Xican Li*, Wengqiong Mai, Li Wang, Weijuan Han. A Hydroxyl-scavenging Assay Based on DNA Damage in vitro. Analytical Biochemistry. 2013, 438, 29-31.
›Xican Li*. Solvent Effects and Improvements in the Deoxyribose Degradation Assay for Hydroxyl Radical-scavenging. Food Chemistry. 2013, 141, 2083-2088.
›Xican Li*. Improved pyrogallol autoxidation method: A reliable and cheap superoxide-scavenging assay suitable for all antioxidants. Journal of Agricultural & Food Chemistry. 2012, 60, 6418-6424.
›Xican Li#, Gang Wei#, Xiaozhen Wang, Dong-Hui Liu*, Ru-Dong Deng, Hui Li, Jian-Hong Zhou, Yi-Wei Li, He-Ping Zeng, Dong-Feng Chen*. Targeting of the sonic Hedgehog Pathway by Atractylenolides Promotes Chondrogenic Differentiation of Mesenchymal Stem Cells. Biological & Pharmaceutical Bulletin. 2012, 35, 1328-1335.
›Xican Li*, Jian Lin, Weijuang Han, Wenqiong Mai, Li Wang, Qiang Li, Dongfeng Chen*. Antioxidant Ability and Mechanism of Rhizoma Atractylodes macrocephala. Molecules. 2012, 17(11), 13457-13472. 白术
›Xican Li*, Jing Lin, Yaoxiang Gao, Weijuang Han, Dongfeng Chen*. Antioxidant Activity and Mechanism of Rhizoma Cimicifugae. Chemistry Central Journal. 2012, 6, 140. 升麻
›Xican Li, Dongfeng Chen*, Ying Mai, Bi Wen, Xiaozhen Wang. Concordance between antioxidant activities in vitro and chemical components of Radix Astragali (Huangqi). Natural Product Research. 2012,26,1050-1053. 黄芪
›Xiaozhen Wang, Xican Li*, Dongfeng Chen. Evaluation of Antioxidant Activity of Isoferulic Acid in vitro. Natural Product Communications. 2011, 6, 1285-1288.
›Ting-Ting Wang, Gong-Chang Zeng, Xi-Can Li, He-Ping Zeng*. In vitro studies on the antioxidant and protective effect of 2-substituted-8-hydroxyquinoline derivatives against H2O2-Induced oxidative stress in BMSCs. Chemical Biological Drug Design, 2010, 75, 214-222.
›Dong-Feng Chen*, Xican Li, Zhiwei Xu, Xiaobing Liu, Shao-Hui Du, Hui Li, Jian-Hong Zhou, He-Ping Zeng, Zi-Chun Hua. Hexadecanoic Acid from Buzhong Yiqi Decoction Induces Proliferation of Bone Marrow Mesenchymal Stem Cells. Journal of Medicinal Food, 2010, 13(4), 967- 970. 补中益气汤
›Wang Guangrong, Li Xican, Zeng Heping*. Synthesis, Antioxidation Activity of(E)-9-p-Tolyl-3-[2-(8-hydroxy-quinol-2-yl)vinyl]-carbazole and(E)-9-(p-Anisyl)-3-[2-(8-hydroxy-quinol-2-yl)vinyl]-carbazole and Their Induction Proliferation of Mesenchymal Stem Cells. Act Chimica Sinica, 2009, 67(9),974-982.
›Xican Li*, Xiaoting Wu, Ling Huang. Correlation between Antioxidant Activities and Phenolic Contents of Radix Angelicae Sinensis. Molecules. 2009, 14, 5349-5361. 当归
邮箱
lixican@126.com 或 lixc@gzucm.edu.cn
科研主页
中文版： https://www.scholarmate.com/P/NrQN7f
English Version： https://www.researchgate.net/profile/Xican-Li
E-mails: lixican@126.com; lixc@gzucm.edu.cn
ORCID: 0000-0002-4358-3993
