季爱加

副研究员、生药学博士、中药学硕士生导师

教育经历

[1]2013.9-2016.6北京协和医学院-博士

[2]2009.9-2012.6上海海洋大学-硕士

[3]2005.9-2009.6海南大学-学士

工作经历

[1]2017.9-至今新葡的京集团35222vip-副研究员

研究方向：中药资源学

研究领域：

[1]药用植物功能基因组学

[2]药用植物活性成分合成的转录调控机制

联系方式：ajji@gzucm.edu.cn

研究课题

[1]广东省自然科学基金面上项目, 2026.01至2028.12，在研，主持

[2]广东省教育厅特色创新类项目，项目编号：2025KTSCX0 25，2025.10至2027.9，在研，主持

[3]广州市基础研究计划“青年博士启航”项目，项目编号：SL2024A04J01476，2025.01至2026.12，在研，主持

[4]新葡的京集团35222vip“固本”工程一级学科能力提升项目，2025.4-2027.12，在研，主持

[5]广东省中医药局科研项目, 项目编号：20241085，2024. 01至2025.12，在研，主持 

[6]广东省自然科学基金面上项目, 项目编号：2022A15150 10646，2022.01至2025.12，在研，主持

[7]国家自然科学基金青年基金，项目编号：82003895，2021. 01至2023.12，结题，主持

[8]广东省自然科学基金青年项目，项目编号：2019A1515 110594，2020.01至2022.7，结题，主持

[9]广东省教育厅广东省普通高校青年创新人才项目，项目编号：2017KQNCX038，2018.01至2019.12，结题，主持

[10]新葡的京集团35222vip高水平大学建设杏林人才项目，项目编号：A1-2606-18-414-029，2017.09至2021.09，结题，主持；

[11]科技部基础资源调查专项，项目编号：2018FY100700，20 19.01至2024.12，结题，参加。

主编或参编教材及著作

[1]《药用植物分子遗传学》，十四五规划教材，科学出版社，2025，编委

[2]《药用植物分子遗传学》，著作，科学出版社，2022，编委

代表性论文论著

[1]Baolian Fan^#, Zhongju Ji^#, Min Zhu, Yidu Chen, Jincai Liang, Yu Li, Runxiang Yi, Chenxu Liu, Lijun Wang, Ningwei Shi, Tingxing Yang, Ruoshi Huang, Lu Yang, Aijia Ji*, Zhongqiu Liu*, Lixin Duan*. Elucidation of the biosynthetic pathways of timosaponins reveals the antifungal mechanisms in Anemarrhena asphodeloides. Journal of Advanced Research, 2025,30:S2090-1232(25)00068-2. doi: 10.1016/j.jare.2025.01.049.

[2]Shun Xu^#, Zhuoyi Zhang^#, Wupeng Ma, Jitong Chen, Wei Sun, Rui Guan, Libing Zhang, Jing Li, Zhongqiu Liu*, Lixin Duan*, Aijia Ji*. Identification of allelochemicals and investigation of the mechanism of action of Andrographis paniculata. Plant Physiology and Biochemistry, 2025, 229(PartA). doi:10.1016/j.plaphy.2025.110295.

[3]Zhuoyi Zhang, Ningwei Shi, Lirong Su, Jitong Chen, Wupeng Ma, Xinyao Chen, Zhongqiu Liu*, Lixin Duan*, Aijia Ji*. Oxidosqualene cyclases and cytochrome P450s involved in the biosynthesis of diverse triterpenes in Centipeda minima. International Journal of Biological Macromolecules, 2025,329:147942. doi:10.1016/j.ijbiomac. 2025.147942.

[4]Wei Yao^#, Lirong Su^#, Zhimei Lu, Jitong Chen, Lixin Duan, Xiangxiao Meng, Huihua Wan, Yaolei Mi*, Aijia Ji*. Genomic characterization of AP2/ERF transcription factors related tocannabinoids biosynthesis in Cannabis sativa. Chinese Herbal Medicines, 2025, doi:10.1016/j.chmed. 2025.06.001

[5]Rui Guan#, Shun Xu#, Zhimei Lu, Lirong Su, Libing Zhang, Wei Sun, Yu Zhang, Chunhong Jiang, Zhongqiu Liu*, Lixin Duan*, Aijia Ji*. Genomic characterization of bZIP transcription factors related to andrographolide biosynthesis in Andrographis paniculata. International Journal of Biological Macromolecules, 2022, 223:1619–1631 doi: 10.1016/j.ijbiomac.2022.10.283

[6]Libing Zhang#, Rui Guan#, Guangli Li, Kexin Su, Lixin Duan, Wei Sun, Xiangxiao Meng, Huihua Wan, Sifan Wang, Shilin Chen, Yaolei Mi*, Aijia Ji*. Genomic identification of ARF transcription factors and expression analysis in Cannabis sativa L. Industrial Crops & Products, 2022,186:115118 doi: 10.1016/j.indcrop.2022.115118

[7]Guangli Li#, Tianyue An#, Yu Li, Jinyang Yue, Ruoshi Huang, Jia Huang, Jincai Liang, Wei Yao, Liufang Huang, Yidu Chen, Rongrong Zhang, Aijia Ji* and Lixin Duan*. Transcriptome analysis and identification of the cholesterol side chain cleavage enzyme BbgCYP11A1 from Bufo bufo gargarizans. Frontiers in Genetics, 2022,13:828877. doi: 10.3389/fgene.2022.828877.

[8]Yunpeng Wang, Wenbo Xiong, Yidu Chen, Min Zhu, Jincai Liang, Yu Li, Jia Huang, Liufang Huang, Zhongqiu Liu, Aijia Ji*, Lixin Duan*. Transcriptomic investigation of the biochemical function of 7-dehydrocholesterol reductase 1 from the traditional Chinese medicinal plant Anemarrhena asphodeloides Bunge. Phytochemistry, 2021,192:112954.

[9]Jia Huang, Jing Li, Jingyang Yue, Zilu Huang, Libing Zhang, Wei Yao, Rui Guan, Jianlian Wu, Jincai Liang, Lixin Duan* and Aijia Ji*. Functional characterization of a novel glycosyltransferase (UGT73CD1) from Iris tectorum Maxim. for the substrate promiscuity, Molecular Biotechnology, 2021, 63, 1030–1039. doi: 10.1007/s12033-021-00364-1

[10]Rongrong Zhang#, Zhenzhen Chen#, Libing Zhang, Wei Yao, Zhichao Xu, Baosheng Liao, Yaolei Mi, Han Gao, Chunhong Jiang, Lixin Duan* and Aijia Ji*. Genomic Characterization of WRKY Transcription Factors Related to Andrographolide Biosynthesis in Andrographis paniculata. Frontiers in Genetics, 2021,11:601689.

[11]Wei Yao#, Tianyue An#, Zhichao Xu, Libing Zhang, Han Gao, Wei Sun, Baosheng Liao, Chunhong Jiang, Zhongqiu Liu*, Lixin Duan* and Aijia Ji*. Genomic-wide identification and expression analysis of AP2/ERF transcription factors related to andrographolide biosynthesis in Andrographis paniculata, Industrial Crops & Products, 2020,157. doi: 10.1016/j.indcrop.2020.112878

[12]Yu Zhang#, Aijia Ji#, Zhichao Xu, Hongmei Luo, Jingyuan Song*. The AP2/ERF transcription factor SmERF128 positively regulates diterpenoid biosynthesis in Salvia miltiorrhiza. Plant Molecular Biology. 2019, 100 (1-2):83-93. doi: 10.1007/s11103-0 19-00845-7.

[13]Aijia Ji#, Jing Jia#, Zhichao Xu, Ying Li, Wu Bi, Fengming Ren, Chunnian He, Jie Liu, Kaizhi Hu*, Jingyuan Song*. Transcriptome-guided Ming of Genes Involved in Crocin Biosynthesis, Frontiers in Plant Science. 2017 8:518. doi: 10.3389/fpls.2017.00518.

[14]Aijia Ji, Hongmei Luo, Zhichao Xu, Xin Zhang, Yingjie Zhu, Baosheng Liao, Hui Yao, Jingyuan Song*, Shilin Chen*. Genome-wide identification of the AP2/ERF gene family involved in active constituent biosynthesis in Salvia miltiorrhiza, Plant Genome. 2016 9(2),1-11.

[15]Aijia Ji#, Qing Ma#, Muyan Kong#, Leyan Li, Xinlian Chen, Zhongqiu Liu, Jinjun Wu*, Rong-Rong Zhang*. Two cardenolide glycosides from the seed fairs of Asclepias curassavica L. and their cytotoxic activities, Chinese Journal of Natural Medicines. 2022, 20 (2): 1-8. doi: 10.1016/S1875-5364(21)60098-5.

[16]Shidan Wu#, Fan Zhang#, Wenbo Xiong, Istvan Molnar, Jincai liang, Aijia Ji, Yu Li, Caixia Wang, Shengliang Wang, Zhongqiu Liu*, Ruibo Wu*, and Lixin Duan*. An Unexpected Oxidosqualene Cyclase Active Site Architecture in the Iris tectorum Multifunctional α-Amyrin Synthase, ACS catalysis. 2020,10(16), 9515–9520.

[17]Yu Zhang, Zhichao Xu, Aijia Ji, Hongmei Luo, Jingyuan Song*. Genomic Survey of bZIP Transcription Factor Genes Related to Tanshinone Biosynthesis in Salvia miltiorrhiza [J]. Acta Pharmaceutica Sinica B, 2018, 8(2):295-305.

[18]Zhichao Xu, Aijia Ji, Xin Zhang, Jingyuan Song*, Shilin Chen*. Biosynthesis and Regulation of Active Constituents in Medicinal Model Plant Salvia miltiorrhiza. Chinese Herbal Medicines, 2016, 8(1): 3-11.

[19]Haibin Xu#, Jingyuan Song#, Hongmei Luo#, Yujun Zhang, Qiushi Li, Yingjie Zhu, Jiang Xu, Ying Li, Chi Song, Bo Wang, Wei Sun, Guoan Shen, Xin Zhang, Jun Qian, Aijia Ji, Zhichao Xu, Xiang Luo, Liu He, Chuyuan Li, Chao Sun, Haixia Yan, Guanghong Cui, Xiwen Li, Xian'en Li, Jianhe Wei, Juyan Liu, Yitao Wang, Alice Hayward, David Nelson, Zemin Ning, Reuben J. Peters, Xiaoquan Qi*, Shilin Chen*, Analysis of the genome sequence of the medicinal plant Salvia miltiorrhiza, Molecular Plant, 2016, 9(6): 949-952.

其他代表性业绩

授权专利

[1]段礼新，刘中秋，王丽君，梁锦才，季爱加. 一种源于知母的β-葡萄糖苷酶、其编码基因、表达载体及其应用. 中国，ZL201910216451.1，2022-03-25.

[2]季爱加，陈珍珍，段礼新，刘中秋，李静，吴世丹，陈义都. 一种丹参转录因子SmNAC78基因及其表达载体的应用. 中国，ZL202011038347.7，2022-03-08.

[3]段礼新，刘中秋，吴世丹，黄柳芳，季爱加，梁锦才. 一种用于催化合成香树素的蛋白及其制备方法和应用. 中国，ZL202010622749.5, 2021-12-24.

[4]宋经元，张瑜，季爱加. 一种丹参AP2转录因子SmERF128编码序列及克隆方法与应用. 中国，ZL201810285885.2，2021-09-21.

[5]罗红梅，张建红，吕海舟，宋经元，季爱加. 一种调控丹参酮生物合成的SmAP2/ERF82转录因子的筛选、鉴定及应用. 中国，ZL201710849664.9，2021-08-31.